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PubMed · 14499265

Granulysin.

Carol Clayberger·Alan M Krensky
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Abstract

Granulysin, a molecule expressed by human natural killer cells and activated T lymphocytes, exhibits cytolytic activity against a variety of microbes and tumors. Progress in understanding the structure, function and clinical relevance of granulysin over the past year encompasses three main areas: first, the solution of its crystal structure, providing new insights into its potential mechanism of target cell damage; second, inhibition of its function with small interfering RNA, indicating its relevance in microbial immunity; and third, association of granulysin expression in natural killer cells with good outcomes in cancer, indicating its potential utility as a diagnostic and suggesting its relevance to human disease.

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Amino Acid SequenceAntigens, Differentiation, T-LymphocyteApoptosisCommunicable DiseasesCytoplasmic GranulesHumansJurkat CellsKiller Cells, NaturalModels, MolecularNeoplasmsReceptors, ImmunologicSequence Homology, Amino AcidT-Lymphocytes, CytotoxicJournal ArticleReview

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Carol Clayberger, Alan M Krensky. 2003. Granulysin.. https://doi.org/10.1016/s0952-7915(03)00097-9

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