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RNA interference and chemically modified siRNAs.

Muthiah Manoharan
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Abstract

RNA interference (RNAi) represents one of the most promising new frontiers in drug discovery. Short double-stranded RNA molecules are able to sequence-specifically inhibit expression of genes. This young technology offers both opportunities and challenges to nucleic acid chemists.

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Muthiah Manoharan. 2003. RNA interference and chemically modified siRNAs.. https://doi.org/10.1093/nass%2F3.1.115

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