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Oligonucleotide duplex stabilization by end-linked terpyridine x Cu(II) complexes.

Masaki Hirose·Satoshi Sakamoto·Yasuo Uekita·Masaya Kitamura·Hideo Inoue
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Abstract

As a part of our recent studies of RNA cleavage using antisense oligonucleotide-metal complex(es) conjugates, we prepared self-complementary 2'-O-methyloligonucleotides with a terpyridine x Cu(II) complex, which was attached to the sugar portion of the 5'-end or 3'-end. The thermal stabilities of the formed duplexes, as compared with those of the unmodified 2'-O-methyl duplexes, revealed that both the 5'- and 3'-complexes greatly enhanced the duplex stability.

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Masaki Hirose, Satoshi Sakamoto, Yasuo Uekita, Masaya Kitamura, Hideo Inoue. 2003. Oligonucleotide duplex stabilization by end-linked terpyridine x Cu(II) complexes.. https://doi.org/10.1093/nass%2F3.1.135

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