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Integrin avidity regulation: are changes in affinity and conformation underemphasized?

Christopher V Carman·Timothy A Springer
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Abstract

Integrins play critical roles in development, wound healing, immunity and cancer. Central to their function is their unique ability to modulate dynamically their adhesiveness through both affinity- and valency-based mechanisms. Recent advances have shed light on the structural basis for affinity regulation and on the signaling mechanisms responsible for both affinity and valency modes of regulation.

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Adaptor Proteins, Signal TransducingAnimalsApoptosis Regulatory ProteinsBinding SitesCell AdhesionCell MembraneCell MovementCell PolarityHumansIntegrinsLymphocyte Function-Associated Antigen-1Molecular ConformationMonomeric GTP-Binding ProteinsProtein BindingProtein Structure, TertiaryProtein SubunitsSignal TransductionTalinrap1 GTP-Binding ProteinsJournal ArticleReview

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Christopher V Carman, Timothy A Springer. 2003. Integrin avidity regulation: are changes in affinity and conformation underemphasized?. https://doi.org/10.1016/j.ceb.2003.08.003

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