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PubMed · 14520015

Complement in renal transplantation.

P Chowdhury·W Zhou·S H Sacks
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Abstract

Previous research and therapy in renal transplantation largely focused on the cellular arm of the adaptive immune response. Evidence is emerging that innate immune mechanisms, particularly complement, play a greater role in inflammatory and immune responses against the graft than has been previously recognized. Alternative complement pathway activation appears to mediate renal ischaemia/reperfusion injury, and proximal tubular cells may be both the source and the site of attack of complement components in this setting. Locally produced complement also plays a role in the development of both cellular and antibody-mediated immune responses against the graft. C4d staining has emerged as a useful marker of humoral rejection both in the acute and in the chronic setting and led to renewed interest in the significance of anti-donor antibody formation. A number of therapies are in development which inhibit complement or reduce local synthesis, and may lead to an improved clinical outcome following renal transplantation.

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Complement C4Complement C4bComplement System ProteinsGraft RejectionHumansKidney TransplantationPeptide FragmentsReperfusion InjuryJournal ArticleResearch Support, Non-U.S. Gov'tReview

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P Chowdhury, W Zhou, S H Sacks. 2003. Complement in renal transplantation.. https://doi.org/10.1159/000073012

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