[Anti-IgE therapy].

Ryszarda Chazan

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PubMed · 14524285

[Anti-IgE therapy].

Ryszarda Chazan

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Abstract

Atopy--the genetic predisposition to produce allergen-specific IgE is one of the most important predisposing factors for the development of asthma and other allergic diseases. Because of pivotal place of IgE in early and late phase e of allergic responses the introduction of anti-IgE antibodies to therapy provides a novel and promising approach to treatment of asthma and other IgE-dependent diseases. The administration of anti-IgE reduces circulating IgE levels to less than 1% of the baseline value and down-regulates the expression of basophil IgE receptors. Anti-IgE antibody rhuMAb E25 (omalizumab) improved asthma symptoms, reduced the rates of exacerbations and allowed for the reduction of corticosteroids and rescue medication doses. Anti-IgE therapy is safe and well tolerated.

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Antibodies, Anti-Idiotypic Antibodies, Monoclonal Antibodies, Monoclonal, Humanized Asthma Humans Immunoglobulin E Omalizumab English Abstract Journal Article Review

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Ryszarda Chazan. 2003. [Anti-IgE therapy].. https://pubmed.ncbi.nlm.nih.gov/14524285/

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