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Dynamic multivalent lactosides displayed on cyclodextrin beads dangling from polymer strings.

Alshakim Nelson·J Fraser Stoddart
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Abstract

[reaction: see text] Lactose-appended cyclodextrin derivatives have been synthesized and threaded onto hydrophobic polymers in aqueous solution to form dynamic multivalent lactosides for binding to lectins. The threading process, which proceeds quickly, can be observed by one- and two-dimensional NMR spectroscopies.

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Carbohydrate ConformationCarbohydrate SequenceCyclodextrinsGlycosidesLectinsMagnetic Resonance SpectroscopyMolecular Sequence DataPolymersThermodynamicsJournal ArticleResearch Support, U.S. Gov't, Non-P.H.S.

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Alshakim Nelson, J Fraser Stoddart. 2003-10-16. Dynamic multivalent lactosides displayed on cyclodextrin beads dangling from polymer strings.. https://doi.org/10.1021/ol0353464

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