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PubMed · 145499

DNA replication in bacteriophage-infected Staphylococcus aureus.

M H Ubelaker·E D Rosenblum
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Abstract

The synthesis of viral and host DNA in phage-infected Staphylococcus aureus was examined. Three intracellular forms of phage 52HJD DNA were demonstrated: covalently closed circular, open circular, and linear DNA species. It was noted that infection of S. aureus-propagating strains 81 and 52 with phage 52HJD inhibited the replication of the bacterial chromosome and a stringently controlled penicillinase plasmid. A small tetracycline plasmid, normally under relaxed replication control, continued to replicate in the postinfection period. No breakdown of the host chromosome into small-molecular-weight fragments or utilization of bacterial DNA material for the synthesis of viral DNA was observed.

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DNA, BacterialDNA, CircularDNA, ViralNucleic Acid ConformationPenicillinasePlasmidsStaphylococcus PhagesStaphylococcus aureusTetracyclineJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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M H Ubelaker, E D Rosenblum. 1977. DNA replication in bacteriophage-infected Staphylococcus aureus.. https://doi.org/10.1128/jvi.24.3.768-774.1977

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