Sulphonamide-based small molecule VLA-4 antagonists.

Marcin Stasiak; Christopher Mehlin; Erica Boni; Tomas Vaisar; Thomas Little; Hwa-Ok Kim; Maher Qabar

doi:10.1016/s0960-894x(03)00760-1

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Sulphonamide-based small molecule VLA-4 antagonists.

Marcin Stasiak·Christopher Mehlin·Erica Boni·Tomas Vaisar·Thomas Little·Hwa-Ok Kim·Maher Qabar

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Abstract

The discovery of a sulphonamide by-product with VLA-4 antagonistic activity led to a series of potent, small molecule VLA-4 antagonists. Synthesis, SAR and in vivo evaluation of the selected compound will be presented.

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Animals Asthma Cell Adhesion Cell Line Cell Movement Eosinophils Female Half-Life Indicators and Reagents Integrin alpha4beta1 Leukocytes Macaca fascicularis Mice Mice, Inbred BALB C Ovalbumin Structure-Activity Relationship Sulfonamides Journal Article

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Marcin Stasiak, Christopher Mehlin, Erica Boni, Tomas Vaisar, Thomas Little, Hwa-Ok Kim, Maher Qabar. 2003-11-03. Sulphonamide-based small molecule VLA-4 antagonists.. https://doi.org/10.1016/s0960-894x(03)00760-1

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