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Chronic myeloid leukemia.

Richard T Silver
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Abstract

Chronic myeloid leukemia is a clonal myeloproliferative disorder of a pluripotent stem cell with a specific cytogenetic abnormality, the Philadelphia chromosome, involving myeloid, erythroid, megakaryocytic, B lymphoid, and sometimes T lymphoid cells but not marrow fibroblasts. Advances in cell biology and molecular genetics and a plethora of biochemical, cytogenetic, and molecular data of clinical relevance have yielded much new information regarding this disease. This article reviews the hematologic and clinical aspects of chronic myeloid leukemia; discusses the pertinent aspects of the advances in understanding of the cytogenetics and molecular biology of the disease; and reviews treatment programs employing busulfan, hydroxyurea, interferon, and marrow transplantation, which still are clinically important and relevant despite the development of the exciting new drug imatinib mesylate, a new paradigm for cancer chemotherapy in general.

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Bone Marrow TransplantationChromosome AberrationsFemaleFusion Proteins, bcr-ablHumansInterferonsLeukemia, Myelogenous, Chronic, BCR-ABL PositiveMaleJournal ArticleReview

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Richard T Silver. 2003. Chronic myeloid leukemia.. https://doi.org/10.1016/s0889-8588(03)00088-1

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