[Apoptosis modulators].

A A Fil'chenkov

PubMed · 14562680

[Apoptosis modulators].

Abstract

At least two types of cell death are known: physiological (apoptosis) and pathological (necrosis). Dysregulation of apoptosis plays an important role in the pathogenesis of many pathological conditions. Their analysis gives a key for the development of novel therapeutic approaches. In this review the recent advances and perspectives for clinical use of apoptosis-modulating monoclonal antibodies, low-molecular-weight proteins, peptides, small non-peptide molecules and drugs targeting apoptosis-associated genes are summarized. The rationale for clinical application of apoptomodulators with the aim of increasing efficacy of existing standard therapies are also discussed.

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Animals Antibodies, Monoclonal Apoptosis Cytokines Drug Therapy, Combination Enzyme Inhibitors Genetic Therapy Genetic Vectors Humans Oligonucleotides, Antisense Peptide Fragments Proteins English Abstract Journal Article Review

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A A Fil'chenkov. [Apoptosis modulators].. https://pubmed.ncbi.nlm.nih.gov/14562680/

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