Phosphono peptide nucleic acids with a constrained hydroxyproline-based backbone.

Vladimir A Efimov; Valeryi N Klykov; Oksana G Chakhmakhcheva

doi:10.1081/ncn-120021962

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Phosphono peptide nucleic acids with a constrained hydroxyproline-based backbone.

Vladimir A Efimov·Valeryi N Klykov·Oksana G Chakhmakhcheva

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Abstract

DNA mimics representing negatively charged analogues of peptide nucleic acids (PNAs), particularly hetero-oligomers constructed from alternating phosphono-PNA residues (pPNA) and monomers on the base of trans-4-hydroxy-L-proline (HypNA) as well as mimics composed of phosphono-HypNA monomers (pHypNA) were tested in a set of in vitro and in vivo assays, and they demonstrated a high potential for the use in nucleic acid based diagnostic, isolation of nucleic acids and antisense experiments.

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Base Sequence DNA Hydroxyproline Models, Molecular Molecular Conformation Nucleic Acid Conformation Oligodeoxyribonucleotides Oligoribonucleotides Organophosphonates Peptide Nucleic Acids RNA Journal Article

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Vladimir A Efimov, Valeryi N Klykov, Oksana G Chakhmakhcheva. Phosphono peptide nucleic acids with a constrained hydroxyproline-based backbone.. https://doi.org/10.1081/ncn-120021962

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