Urinary modified nucleosides as tumor markers.

E Dudley; F Lemiere; W Van Dongen; E Esmans; A M M El-Sharkawi; D E Games; A G Brenton; R P Newton

doi:10.1081/ncn-120022719

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Urinary modified nucleosides as tumor markers.

E Dudley·F Lemiere·W Van Dongen·E Esmans·A M M El-Sharkawi·D E Games·A G Brenton·R P Newton

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Abstract

Extracts of urinary nucleosides have been sequentially purified and examined by mass spectrometric analysis. Seventeen modified nucleosides have been unequivocally identified and a further five provisionally identified. While several nucleosides were found only in a small number of extracts, the occurrence and levels of others were found to correlate with the tumour type and stage.

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Biomarkers, Tumor Chromatography, High Pressure Liquid Gas Chromatography-Mass Spectrometry Humans Mass Spectrometry Neoplasm Staging Neoplasms Nucleosides Journal Article

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E Dudley, F Lemiere, W Van Dongen, E Esmans, A M M El-Sharkawi, D E Games, A G Brenton, R P Newton. Urinary modified nucleosides as tumor markers.. https://doi.org/10.1081/ncn-120022719

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