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Novel base-labile protecting groups for 5'-hydroxy function in solid-phase oligonucleotide synthesis.

Kazuo Kamaike·Takashi Namiki·Etsuko Kawashima
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Abstract

The 6-(levulinyloxymethyl)-3-methoxy-2-nitrobenzoyl (LMMoNBz) and 2-(levulinyloxymethyl)-5-methoxy-4-nitrobenzoyl (LMMpNBz) groups were developed as novel base-labile protection for the 5'-hydroxy function in solid-phase oligonucleotide synthesis. A comparative study of the LMMoNBz, LMMpNBz and 2-(levulinyloxymethyl)-5-nitrobenzoyl (LMNBz) protecting groups for oligonucleotide synthesis proved strong feasibility for the LMMoNBz group.

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Chromatography, High Pressure LiquidHydroxylationIndicators and ReagentsMolecular StructureOligonucleotidesStructure-Activity RelationshipThymineJournal Article

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Kazuo Kamaike, Takashi Namiki, Etsuko Kawashima. Novel base-labile protecting groups for 5'-hydroxy function in solid-phase oligonucleotide synthesis.. https://doi.org/10.1081/ncn-120022725

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