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Nucleobase modified peptide nucleic acid.

R H E Hudson·R D Viirre·N McCourt·J Tse
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Abstract

The Pd0/Cu1 catalyzed cross-coupling of terminal alkynes onto peptide nucleic acid monomers or submonomers bearing iodinated nucleobases has been utilized as a route to base-modified oligomers. Both 5-iodouracil and 5-iodocytosine derivatives undergo the cross-coupling to give the expected products in moderate to good yields. However, depending on the particular substrates and reaction conditions, the cross-coupling may be followed by a ring closing reaction to give the fluorescent furano- and pyrrolo-fused uracil and cytosine derivatives, respectively.

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Binding SitesCross-Linking ReagentsCytosineIndicators and ReagentsKineticsMolecular StructurePeptide Nucleic AcidsUracilJournal ArticleResearch Support, Non-U.S. Gov't

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R H E Hudson, R D Viirre, N McCourt, J Tse. Nucleobase modified peptide nucleic acid.. https://doi.org/10.1081/ncn-120022728

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