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Significant association of HLA A2-DR11 with CD4 naive decrease in autistic children.

Pasquale Ferrante·Marina Saresella·Franca R Guerini·Michela Marzorati·Maria C Musetti·Adriana Guareschi Cazzullo
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Abstract

Nine autistic children and 37 ethnically homogenous controls were enrolled in the study to assess their human leukocyte antigen (HLA) pattern, and eight healthy children were studied to define their peripheral blood cell subsets. We observed a significant decrease in CD4+ naive and an increase in CD4+ memory T cells in autistic children. These differences were significantly more pronounced in the autistic children bearing the HLA A2 and DR11 alleles. These data support the hypothesis that autism could be due to an immune imbalance occurring in genetically predisposed children.

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Autistic DisorderCD4 Lymphocyte CountCD4-Positive T-LymphocytesChildFemaleFlow CytometryGene FrequencyHLA-A2 AntigenHLA-DR AntigensHLA-DR Serological SubtypesHumansMaleJournal ArticleResearch Support, Non-U.S. Gov't

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Pasquale Ferrante, Marina Saresella, Franca R Guerini, Michela Marzorati, Maria C Musetti, Adriana Guareschi Cazzullo. 2003. Significant association of HLA A2-DR11 with CD4 naive decrease in autistic children.. https://doi.org/10.1016/s0753-3322(03)00099-4

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Oxidative stress in autism: increased lipid peroxidation and reduced serum levels of ceruloplasmin and transferrin--the antioxidant proteins.

Autism is a neurological disorder of childhood with poorly understood etiology and pathology. We compared lipid peroxidation status in the plasma of children with autism, and their developmentally normal non-autistic siblings by quantifying the levels of malonyldialdehyde, an end product of fatty acid oxidation. Lipid peroxidation was found to be elevated in autism indicating that oxidative stress is increased in this disease. Levels of major antioxidant proteins namely, transferrin (iron-binding protein) and ceruloplasmin (copper-binding protein) in the serum, were significantly reduced in autistic children as compared to their developmentally normal non-autistic siblings. A striking correlation was observed between reduced levels of these proteins and loss of previously acquired language skills in children with autism. These results indicate altered regulation of transferrin and ceruloplasmin in autistic children who lose acquired language skills. It is suggested that such changes may lead to abnormal iron and copper metabolism in autism, and that increased oxidative stress may have pathological role in autism.

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