Lactoferrin--a multifunctional protein with antimicrobial properties.

Sebastien Farnaud; Robert W Evans

doi:10.1016/s0161-5890(03)00152-4

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Lactoferrin--a multifunctional protein with antimicrobial properties.

Sebastien Farnaud·Robert W Evans

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Abstract

Lactoferrin is a member of the transferrin family of iron-binding proteins. Numerous functions have been reported and continue to be reported for the protein, some of which are related to its iron-binding properties. Its extensive antimicrobial activities were originally attributed to its ability to sequester essential iron, however, it is now established that it possesses bactericidal activities as a result of a direct interaction between the protein or lactoferrin-derived peptides. This article reviews the antimicrobial activities of lactoferrin and discusses the potential mode of action of lactoferrin-derived cationic peptides against Gram-negative bacteria in the light of recent studies.

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Animals Anti-Bacterial Agents Gram-Negative Bacteria Humans Iron Lactoferrin Journal Article Research Support, Non-U.S. Gov't Review

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Sebastien Farnaud, Robert W Evans. 2003. Lactoferrin--a multifunctional protein with antimicrobial properties.. https://doi.org/10.1016/s0161-5890(03)00152-4

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