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PubMed · 14570579

SNARE protein structure and function.

Daniel Ungar·Frederick M Hughson
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Abstract

The SNARE superfamily has become, since its discovery approximately a decade ago, the most intensively studied element of the protein machinery involved in intracellular trafficking. Intracellular membrane fusion in eukaryotes requires SNARE (soluble N-ethylmaleimide-sensitive-factor attachment protein receptor) proteins that form complexes bridging the two membranes. Although common themes have emerged from structural and functional studies of SNAREs and other components of the eukaryotic membrane fusion machinery, there is still much to learn about how the assembly and activity of this machinery is choreographed in living cells.

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AnimalsHumansIntracellular MembranesMacromolecular SubstancesMembrane FusionMembrane ProteinsNerve Tissue ProteinsProtein Structure, TertiaryProtein TransportSNARE ProteinsVesicular Transport Proteinsrab GTP-Binding ProteinsJournal ArticleReview

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Daniel Ungar, Frederick M Hughson. 2003. SNARE protein structure and function.. https://doi.org/10.1146/annurev.cellbio.19.110701.155609

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