Leukemia inhibitory factor--a puzzling polyfunctional regulator.

D Metcalf

doi:10.3109/08977199209046921

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Leukemia inhibitory factor--a puzzling polyfunctional regulator.

D Metcalf

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Abstract

LIF seems likely to have important functions in the early developing embryo and in adult life can influence platelet formation, osteoblast and neuronal function, calcium and lipid metabolism and the production of acute-phase proteins. LIF appears usually to be produced and to function locally in various tissues, an arrangement that would minimize unwanted actions of this polyfunctional regulator. Nevertheless it remains puzzling what purpose is achieved by use of a regulator with potent actions on such a wide range of apparently unrelated tissues.

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Animals Embryo, Mammalian Growth Inhibitors Hematopoiesis Hematopoietic Stem Cells Humans Interleukin-6 Leukemia Inhibitory Factor Leukemia Inhibitory Factor Receptor alpha Subunit Lymphokines Receptors, Cytokine Receptors, Immunologic Receptors, OSM-LIF Journal Article Review

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D Metcalf. 1992. Leukemia inhibitory factor--a puzzling polyfunctional regulator.. https://doi.org/10.3109/08977199209046921

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