PubMed · 14578510
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Davide Ricci, Pier Carlo Braga. 2004. Imaging methods in atomic force microscopy.. https://doi.org/10.1385/1-59259-647-9%3A13
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NIR-FT-Raman spectroscopy was used for identification and quantification of harpagoside in secondary roots of Harpagophytum procumbens as well as in related phytopharmaceutical products, e.g., ethanolic extracts and tablets. Applied Raman mappings reveal the spatial distribution of this valuable iridoid glycoside within the different samples. The same technique can be used for quality control purposes beginning from the plant to its final products. Based on the obtained spectral data and reference HPLC values of harpagoside, a reliable multivariate calibration model was developed.
Europium-154 can be obtained as a by-product from the large-scale production of Samarium-153 and possesses attractive features (t1/2 8.592 yr; Egamma 0.12-1.6 MeV) for use as a reference source similar to 152Eu (t1/2 13.516 yr; Egamma 0.12-1.4 MeV), which is the gold standard for calibration in gamma ray spectrometry. Thermal neutron irradiation of 5mg of 98% enriched 153Sm2O3 target in the reactor led to approximately 200 GBq 153Sm and 1.26 MBq 154Eu. A typical batch control sample of 153SmCl3 solution and final radiopharmaceutical product formulation of 153Sm-phosphonate (153Sm-EDTMP) pooled together contained about 20% of total yield, requiring post decay disposal of 153Sm as radioactive waste. Such spent solutions pooled on quarterly basis led to availing 756 kBq of 154Eu. The radioactivity content and radionuclide purity (approximately 82%) of the recovered 154Eu sample were envisaged as adequate to prepare reference sources for calibration of gamma ray spectrometers. At present, one batch of 153Sm is handled per month at our institution, with the possibility for weekly processing in future. Access to approximately 3.5 MBq of 154Eu on quarterly basis is envisaged, apart from obviating the need for instituting steps to tackle disposal of the long-lived 154Eu in the spent solution. Up to 60-120 units of 20-100 kBq of 154Eu reference sources per year could thus be available by the proposed strategy.
Elevated plasma homocysteine levels may be an independent risk factor for premature vascular disease. Early detection and population screening are warranted to recognise hyperhomocysteinemia and initiate homocysteine lowering therapy. Current methods for homocysteine analysis are time consuming, labor intensive and/or expensive. We developed a sensitive and fast method for homocysteine analysis based on tandem mass spectrometry that avoids the need for derivatization and preanalytical chromatography.