Nuclear hormone receptor co-regulators.

Obaid Yusuf Khan; Zafar Nawaz

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PubMed · 14579519

Nuclear hormone receptor co-regulators.

Obaid Yusuf Khan·Zafar Nawaz

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Abstract

The critical role of nuclear hormone receptor co-activators in gene expression has been extensively studied for the past few years. Co-regulators (co-activators and co-repressors) are known to utilize various enzymatic activities, in addition to molecular interactions, to modulate gene expression in response to hormonal signals. Recent studies that demonstrate the role of co-regulators in cancer and developmental disorders have revealed their possible role as targets of therapy. A greater understanding of the cellular physiology of co-regulators is necessary to explore the pathological ramifications of hormone-dependent diseases, and to discover new treatments.

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Animals Gene Expression Regulation Humans Neoplasms Receptors, Cytoplasmic and Nuclear Transcription Factors Transcription, Genetic Journal Article Research Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.Review

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Obaid Yusuf Khan, Zafar Nawaz. 2003. Nuclear hormone receptor co-regulators.. https://pubmed.ncbi.nlm.nih.gov/14579519/

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