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Improved apparatus for solid-liquid multi-stage counter-current extraction.

Kayoko Tahara·Yoshihiro Abe·Setsuro Sugata·Hideyuki Nishizawa·Takashi Nishikawa·Hiroshi Suzuki·Makoto Takeuchi
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Abstract

An improved apparatus for solid-liquid multi-stage counter-current extraction (SLME) was developed. The apparatus has a set of 24 extraction vessels. Each extraction vessel unit is composed of a piston-cylinder in which the solid phase is placed, and a cup-cylinder in which the liquid phase is set. Of the 24 extraction vessels, 20 were used for the separation stage, and the other 4 were used for the back-extraction stage. (+/-)-Troger's base was selected as a racemic model compound for the continuous enantioseparation by the apparatus, and a cellulose derivative was used as the chiral separator. After 50 cycles of the operation (in 9 h), 0.1 g of (-)-enantiomer (85% in purity) was recovered from the solid phase by back-extraction with ethanol, whereas 1.1 g of (+)-isomer (75% in purity) was collected from the liquid phase (ethanol).

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Chromatography, High Pressure LiquidCountercurrent DistributionStereoisomerismJournal Article

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Kayoko Tahara, Yoshihiro Abe, Setsuro Sugata, Hideyuki Nishizawa, Takashi Nishikawa, Hiroshi Suzuki, Makoto Takeuchi. 2003-10-31. Improved apparatus for solid-liquid multi-stage counter-current extraction.. https://doi.org/10.1016/j.chroma.2003.08.013

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