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PubMed · 14584878

Antigen-specific B-lymphocyte activation.

Gail A Bishop·Sokol A Haxhinasto·Laura L Stunz·Bruce S Hostager
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Abstract

B lymphocytes comprise a major component of the adaptive mammalian immune system, having the exclusive ability to produce and secrete immunoglobulins (Ig) of various forms (isotypes). This property alone renders B-cell activation critical to immunity, but the fully activated B cell also functions in antigen presentation and the production of a variety of cytokines and chemokines. There are many signals that must be coordinated to achieve and properly regulate antigen-specific B-lymphocyte activation and the development of humoral memory. This review seeks to summarize these components, and to highlight recent advances in each area that contribute to a greater understanding of the complex processes involved in B-cell activation.

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AnimalsAntigensAntigens, CDB-LymphocytesHumansImmunoglobulin Class SwitchingLymphocyte ActivationReceptors, Antigen, B-CellT-LymphocytesJournal ArticleReview

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Gail A Bishop, Sokol A Haxhinasto, Laura L Stunz, Bruce S Hostager. 2003. Antigen-specific B-lymphocyte activation.. https://doi.org/10.1615/critrevimmunol.v23.i3.10

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