Cell cycle control in glomerular disease.

Gunter Wolf; Stuart J Shankland

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PubMed · 14593702

Cell cycle control in glomerular disease.

Gunter Wolf·Stuart J Shankland

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Abstract

Glomerular diseases are a leading caused of kidney failure. The three resident glomerular cell types respond differently to injury, which includes proliferation, hypertrophy, apoptosis and de-differentiation. Each leads to glomerular scarring, and a decline in renal function. Studies have shown that these events are critically controlled by cell cycle regulatory proteins, providing potential targets for the development of future therapeutics.

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Animals Apoptosis Cell Cycle Proteins Glomerular Mesangium Glomerulonephritis Humans Hypertrophy Kidney Glomerulus Models, Animal Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.Review

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Gunter Wolf, Stuart J Shankland. 2003. Cell cycle control in glomerular disease.. https://pubmed.ncbi.nlm.nih.gov/14593702/

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