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PubMed · 14599952

A rat model for acute hepatic failure.

Yong He·Jun Zhou·Ke-Feng Dou·Yong Chen
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Abstract

OBJECTIVE: To develop a surgical model of acute hepatic failure. METHODS: Hepatectomy was performed in rats according to the method described by Higgins and Anderson. Ninety percent liver resection (removing the left lateral, median, and right lateral lobes) (n=7) and 95% liver resection leaving only half of the caudate lobe (n=13) were performed. Hypoglycemia was corrected by giving 20% glucose in the drinking water, coupled with repeated intraperitoneal injection of 5% glucose adapted to glycemia. While the survival rate, alanine transaminase (ALT) and bilirubin were observed. RESULTS: 95% liver resection decreased survival rates of the rats from 86% (90% liver resection) to 23% (P<0.05), and increased bilirubin levels (4.04+/-2.84 mg/dL vs. 1.25+/-1.85 mg/dL [90% liver resection]). CONCLUSION: 95% liver resection is a good rat model for acute hepatic failure.

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Alanine TransaminaseAnimalsBilirubinDisease Models, AnimalHepatectomyLiver Failure, AcuteMaleRatsRats, Sprague-DawleyJournal Article

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Yong He, Jun Zhou, Ke-Feng Dou, Yong Chen. 2003. A rat model for acute hepatic failure.. https://pubmed.ncbi.nlm.nih.gov/14599952/

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