Wound healing: future directions.

Ian Appleton

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PubMed · 14600839

Wound healing: future directions.

Ian Appleton

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Abstract

Over the years, numerous attempts have been made to accelerate the wound healing response, with varying degrees of success. This review covers the different phases of repair and attempts to highlight potential therapies, including modulation of re-epithelialization, granulation tissue formation and angiogenesis. Of the plethora of factors involved in these processes, three stand out as future candidates for development. Keratinocyte growth factor is undoubtedly a target for re-epithelialization, transforming growth factor-beta for matrix deposition and vascular endothelial growth factor is a prime target for angiogenesis. Particular emphasis is placed on angiogenesis as this offers perhaps the most intriguing line of therapy.

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Arginine Cyclooxygenase 2 DNA-Binding Proteins Humans Hypoxia-Inducible Factor 1 Hypoxia-Inducible Factor 1, alpha Subunit Isoenzymes Medicine, Traditional Membrane Proteins Neovascularization, Physiologic Nitric Oxide Nuclear Proteins Prostaglandin-Endoperoxide Synthases Transcription Factors Vascular Endothelial Growth Factor A Wound Healing Journal Article Review

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Ian Appleton. 2003. Wound healing: future directions.. https://pubmed.ncbi.nlm.nih.gov/14600839/

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