Solid-phase total synthesis of scytalidamide A.

Wenxin Gu; Richard B Silverman

doi:10.1021/jo0346712

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Solid-phase total synthesis of scytalidamide A.

Wenxin Gu·Richard B Silverman

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Abstract

The first total synthesis of the natural cyclic heptapeptide scytalidamide A was achieved on solid phase using two different resins, a phenylalanine silane resin and a 4-methoxybenzaldehyde backbone linker resin. The synthetic product confirms the structure of the natural product reported in the preceding paper in this issue (Tan, L. T.; Cheng, X. C.; Jensen, P. R.; Fenical, W. J. Org. Chem. 2003, 68, 8767).

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Molecular Structure Nuclear Magnetic Resonance, Biomolecular Peptides, Cyclic Journal Article Research Support, Non-U.S. Gov't

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Wenxin Gu, Richard B Silverman. 2003-11-14. Solid-phase total synthesis of scytalidamide A.. https://doi.org/10.1021/jo0346712

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