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Control of effector CD8+ T cell function by the transcription factor Eomesodermin.

Erika L Pearce·Alan C Mullen·Gislâine A Martins·Connie M Krawczyk·Anne S Hutchins·Valerie P Zediak·Monica Banica·Catherine B DiCioccio·Darrick A Gross·Chai-An Mao·Hao Shen·Nezih Cereb·Soo Y Yang·Tullia Lindsten·Janet Rossant·Christopher A Hunter·Steven L Reiner
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Abstract

Activated CD8+ T cells play a critical role in host defense against viruses, intracellular microbes, and tumors. It is not clear if a key regulatory transcription factor unites the effector functions of CD8+ T cells. We now show that Eomesodermin (Eomes), a paralogue of T-bet, is induced in effector CD8+ T cells in vitro and in vivo. Ectopic expression of Eomes was sufficient to invoke attributes of effector CD8+ T cells, including interferon-gamma (IFN-gamma), perforin, and granzyme B. Loss-of-function analysis suggests Eomes may also be necessary for full effector differentiation of CD8+ T cells. We suggest that Eomesodermin is likely to complement the actions of T-bet and act as a key regulatory gene in the development of cell-mediated immunity.

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Amino Acid SequenceAnimalsArenaviridae InfectionsBase SequenceCD8-Positive T-LymphocytesCell DifferentiationCytotoxicity, ImmunologicGene Expression RegulationGranzymesInterferon-gammaLymphocyte ActivationLymphocytic choriomeningitis virusMembrane GlycoproteinsMiceMice, Inbred BALB CMice, Inbred C57BLMolecular Sequence DataPerforinPore Forming Cytotoxic ProteinsRNA, MessengerSerine EndopeptidasesT-Box Domain ProteinsTh2 CellsTranscription FactorsT-bet Transcription FactorJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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Erika L Pearce, Alan C Mullen, Gislâine A Martins, Connie M Krawczyk, Anne S Hutchins, Valerie P Zediak, Monica Banica, Catherine B DiCioccio, Darrick A Gross, Chai-An Mao, Hao Shen, Nezih Cereb, Soo Y Yang, Tullia Lindsten, Janet Rossant, Christopher A Hunter, Steven L Reiner. 2003-11-07. Control of effector CD8+ T cell function by the transcription factor Eomesodermin.. https://doi.org/10.1126/science.1090148

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