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Simultaneous registration and activation detection for fMRI.

Jeff Orchard·Chen Greif·Gene H Golub·Bruce Bjornson·M Stella Atkins
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Abstract

Registration using the least-squares cost function is sensitive to the intensity fluctuations caused by the blood oxygen level dependent (BOLD) signal in functional MRI (fMRI) experiments, resulting in stimulus-correlated motion errors. These errors are severe enough to cause false-positive clusters in the activation maps of datasets acquired from 3T scanners. This paper presents a new approach to resolving the coupling between registration and activation. Instead of treating the two problems as individual steps in a sequence, they are combined into a single least-squares problem and are solved simultaneously. Robustness tests on a variety of simulated three-dimensional EPI datasets show that the stimulus-correlated motion errors are removed, resulting in a substantial decrease in false-positive and false-negative activation rates. The new method is also shown to decorrelate the motion estimates from the stimulus by testing it on different in vivo fMRI datasets acquired from two different 3T scanners.

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AlgorithmsArtifactsBrainBrain MappingHead MovementsHumansImage EnhancementImage Interpretation, Computer-AssistedImaging, Three-DimensionalMagnetic Resonance ImagingMotionOxygenReproducibility of ResultsSensitivity and SpecificitySubtraction TechniqueComparative StudyEvaluation StudyJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, Non-P.H.S.Validation Study

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Jeff Orchard, Chen Greif, Gene H Golub, Bruce Bjornson, M Stella Atkins. 2003. Simultaneous registration and activation detection for fMRI.. https://doi.org/10.1109/tmi.2003.819294

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