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COX-2 selective inhibitors and bone.

S B Goodman·T Ma·M Genovese·R Lane Smith
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Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) are widely prescribed medications for relief of pain and inflammation. Recent animal studies using models of fracture healing and bone ingrowth suggest that NSAIDs (both non-selective NSAIDs and selective COX-2 inhibitors) adversely affect these bone-related processes. The dose and time-relationships of these medications and their resulting effects on bone have not yet been fully elucidated. Furthermore, whether COX-2 inhibitors and non-selective NSAIDs lead to clinically relevant adverse effects on bone healing in humans is unknown.

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AnimalsBone and BonesCyclooxygenase 2Cyclooxygenase 2 InhibitorsCyclooxygenase InhibitorsHumansIsoenzymesMembrane ProteinsOsteogenesisProstaglandin-Endoperoxide SynthasesJournal ArticleResearch Support, Non-U.S. Gov'tReview

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S B Goodman, T Ma, M Genovese, R Lane Smith. COX-2 selective inhibitors and bone.. https://doi.org/10.1177/039463200301600303

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