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A model for the modulation of microvessel permeability by junction strands.

Bingmei M Fu·Bin Chen
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Abstract

To investigate the effect of junction strands on microvessel permeability, we extend the previous analytical model developed by Fu et al. (1994, J. Biomech. Eng., 116, pp. 502-513), for the interendothelial cleft to include multiple junction strands in the cleft and an interface between the surface glycocalyx layer and the cleft entrance. Based on the electron microscopic observations by Adamson et al. (1998, Am. J. Physiol., 274(43), pp. H1885-H1894), that elevation of intracellular cAMP levels would increase number of tight junction strands, this two-junction-strand and two-pore model can successfully account for the experimental data for the decreased permeability to water, small and intermediate-sized solutes by cAMP.

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AnimalsAnuraCapillariesCapillary PermeabilityCell Membrane PermeabilityComputer SimulationCyclic AMPDiffusionEndothelium, VascularHemorheologyHemostasisIntercellular JunctionsMicrocirculationMicrofluidicsModels, CardiovascularPorosityWaterComparative StudyEvaluation StudyJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.Validation Study

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Bingmei M Fu, Bin Chen. 2003. A model for the modulation of microvessel permeability by junction strands.. https://doi.org/10.1115/1.1611514

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