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Beta-catenin regulates Cripto- and Wnt3-dependent gene expression programs in mouse axis and mesoderm formation.

Markus Morkel·Joerg Huelsken·Maki Wakamiya·Jixiang Ding·Marc van de Wetering·Hans Clevers·Makoto M Taketo·Richard R Behringer·Michael M Shen·Walter Birchmeier
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Abstract

Gene expression profiling of beta-catenin, Cripto and Wnt3 mutant mouse embryos has been used to characterise the genetic networks that regulate early embryonic development. We have defined genes whose expression is regulated by beta-catenin during formation of the anteroposterior axis and the mesoderm, and have identified Cripto, which encodes a Nodal co-receptor, as a primary target of beta-catenin signals both in embryogenesis as well as in colon carcinoma cell lines and tissues. We have also defined groups of genes regulated by Wnt3/beta-catenin signalling during primitive streak and mesoderm formation. Our data assign a key role to beta-catenin upstream of two distinct gene expression programs during anteroposterior axis and mesoderm formation.

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AnimalsBody PatterningCadherinsCytoskeletal ProteinsEmbryonic and Fetal DevelopmentEpidermal Growth FactorGene Expression RegulationGrowth SubstancesMembrane GlycoproteinsMesodermMiceMutagenesisMutationNeoplasm ProteinsProteinsTrans-ActivatorsWnt ProteinsWnt3 Proteinbeta CateninJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.

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Markus Morkel, Joerg Huelsken, Maki Wakamiya, Jixiang Ding, Marc van de Wetering, Hans Clevers, Makoto M Taketo, Richard R Behringer, Michael M Shen, Walter Birchmeier. 2003. Beta-catenin regulates Cripto- and Wnt3-dependent gene expression programs in mouse axis and mesoderm formation.. https://doi.org/10.1242/dev.00859

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