PubMed Health⌕ Search
Home/Archive/PubMed

PubMed · 14631549

Tumor microenvironment and hemorheological abnormalities.

Gianfranco Baronzio·Isabel Freitas·Hau C Kwaan
View original source ↗Export metadata ↓

Abstract

This article reviews the various mechanisms in a malignant tumor that lead to hypoxia, production of tumor interstitial fluid, and rheological changes in its microenvironment. In addition, the associated procoagulant effects are described. The latter phenomenon is the result of complex and dynamic interplay among tumor cells, endothelial cells, circulating blood cells, and angiogenic, clotting, and hemorheological factors. The implications of these abnormalities on therapeutic approach are discussed.

Explore related subjects

Extracellular FluidHemorheologyHumansHypoxiaNeoplasmsThrombosisJournal ArticleReview

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

Gianfranco Baronzio, Isabel Freitas, Hau C Kwaan. 2003. Tumor microenvironment and hemorheological abnormalities.. https://doi.org/10.1055/s-2003-44557

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed2006

Dialysis and nanotechnology: now, 10 years, or never?

Nanotechnology, defined as the science of material features between 10(-9) and 10(-7) of a meter, has received extensive attention in the popular press as proof-of-concept experiments in the laboratory are published. The inevitable delay between feature articles and clinical endpoints has led to unwarranted skepticism about the applicability of the technology to current medical therapy. The theoretic advantages of micro- and nanometer scale engineering to renal replacement include the manufacture of high-hydraulic permeability membranes with implanted sensing and control structures. Recent data in membrane design and testing is presented, with a review of the challenges remaining in implementation of this technology.

Extracellular Fluid↗
PubMed2006

Biology of platelet-derived growth factor and its involvement in disease.

Platelet-derived growth factor (PDGF) is mainly believed to be an important mitogen for connective tissue, especially for fibroblasts that serve in wound healing. However, PDGF also has important roles during embryonal development, and its overexpression has been linked to different types of fibrotic disorders and malignancies. Platelet-derived growth factor is synthesized by many different cell types, and its expression is broad. Its synthesis is in response to external stimuli, such as exposure to low oxygen tension, thrombin, or stimulation by other cytokines and growth factors. In addition, PDGF may function in autocrine stimulation of tumor cells, regulation of interstitial fluid pressure, and angiogenesis. Recently, several drugs were developed that are potent inhibitors of the tyrosine kinase activity of PDGF receptors. Thus, it is important to understand the physiology of PDGF and its receptors and the role of PDGF in different diseases. This review summarizes the physiologic activity of PDGF, the expression of PDGF during embryonal development, and the roles of PDGF expression in nonmalignant disease and in different tumors.

Extracellular Fluid↗
PubMed2006

[Interstitial microdialysis in the clinical and experimental medicine].

Interstitial microdialysis is a minimally invasive method that allows biochemical monitoring of endogenous and exogenous substances in extracellular tissue space. The method is based on sampling of soluble molecules from the interstitial space fluid by means of a semipermeable membrane. Microdialysis has been applied in primary and clinical research of metabolic changes and the blood flow in tissue interstitium and pharmacokinetic drug studies. Results obtained by microdialysis are gradually finding their place in clinical practice as well. This paper is aimed at presenting to the reader new technique of monitoring interstitial metabolism, its advantages, drawbacks and relevance for medicine.

Extracellular Fluid↗