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Effects of nefiracetam, DM-9384 on amnesia and decrease in choline acetyltransferase activity induced by cycloheximide.

T Shiotani·K Tohyama·K Murase·S Ishihara·T Kameyama·T Yamasaki·S Hatanaka·H Kojima·Y Takasu·T Nabeshima
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Abstract

The effects of nefiracetam, [N-(2,6-dimethyl-phenyl)-2-(2-oxo-pyrrolidinyl)acetamide, DM-9384], a cyclic derivative of GABA, were investigated in the cycloheximide (CXM)-induced amnesia animal model using the passive avoidance task. Pre-training administration of DM-9384 attenuated the CXM-induced amnesia as indicated by prolongation of step-down latency. It protected against CXM-induced inhibition of choline acetyltransferase activity in the cerebral cortex. These results suggest that DM-9384 attenuates CXM-induced amnesia by interacting with AChergic neuronal system and enhancing protein synthesis in the brain.

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AmnesiaAnimalsAvoidance LearningBrainCholine O-AcetyltransferaseCycloheximideMaleMicePsychotropic DrugsPyrrolidinonesJournal Article

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T Shiotani, K Tohyama, K Murase, S Ishihara, T Kameyama, T Yamasaki, S Hatanaka, H Kojima, Y Takasu, T Nabeshima. 1992. Effects of nefiracetam, DM-9384 on amnesia and decrease in choline acetyltransferase activity induced by cycloheximide.. https://doi.org/10.1007/bf01250792

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