Running into problems: how cells cope with replicating damaged DNA.

Clare H McGowan

doi:10.1016/j.mrfmmm.2003.08.011

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Running into problems: how cells cope with replicating damaged DNA.

Clare H McGowan

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Abstract

The ability of cells to fully and faithfully replicate DNA is essential for preventing genomic instability and cancer. DNA is susceptible to damage both in resting and in actively replicating cells. Thus, genome duplication necessarily involves replication of damaged DNA. The many mechanism cells use to avoid or overcome the problems of replicating an imperfect DNA template are discussed.

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Animals DNA Damage DNA Repair DNA Replication Eukaryotic Cells Humans Prokaryotic Cells Recombination, Genetic Journal Article Research Support, U.S. Gov't, P.H.S.Review

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Clare H McGowan. 2003-11-27. Running into problems: how cells cope with replicating damaged DNA.. https://doi.org/10.1016/j.mrfmmm.2003.08.011

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