Cell-cycle control during meiotic maturation.

Takeo Kishimoto

doi:10.1016/j.ceb.2003.10.010

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PubMed · 14644189

Cell-cycle control during meiotic maturation.

Takeo Kishimoto

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Abstract

The meiotic cell cycle, which is comprised of two consecutive M-phases, is crucial for the production of haploid germ cells. Although both mitotic and meiotic M-phases share cyclin-B-Cdc2/CDK1 as a key controller, there are meiosis-specific modulations in the regulation of cyclin-B-Cdc2. Recent insights indicate that a common pattern in these modulations can be found by considering the particular activities of mitogen-activated protein kinase (MAPK) during meiosis. The G(2)-phase arrest of meiosis I is released via specific, MAPK-independent signalling that leads to cyclin-B-Cdc2 activation; thereafter, however, the meiotic process is under the control of interplay between MAPK and cyclin-B-Cdc2.

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Animals CDC2 Protein Kinase Cell Cycle Cyclin B Germ Cells Humans MAP Kinase Signaling System Meiosis Models, Biological Signal Transduction Xenopus Journal Article Review

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Takeo Kishimoto. 2003. Cell-cycle control during meiotic maturation.. https://doi.org/10.1016/j.ceb.2003.10.010

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