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Experience with intraperitoneal alpha-2a interferon.

M O Nicoletto·M V Fiorentino·O Vinante·A Prosperi·F Tredese·S Tumolo·G P Cima·S Monfardini
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Abstract

Eighteen patients affected with epithelial ovarian cancer have been treated by intraperitoneal alpha 2a-Interferon. The usual single dosage was 54 x 10(6) U at weekly intervals for four times (eight times in responders): 10 histologically confirmed complete remissions and 3 partial remissions have been obtained; the toxicity was represented by fever in the majority of the cases, by abdominal discomfort in some cases, and by a mild transitory neurological complication in 1 case. Seventeen of 18 patients were pretreated, and 11 of 18 had only cytologic and/or microscopic disease. alpha 2a-Interferon has proven to be very effective and moderately toxic in microscopic peritoneal disease of ovarian epithelial cancer previously treated with extensive surgery and intravenous cytotoxic chemotherapy.

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FemaleHumansInjections, IntraperitonealInterferon alpha-2Interferon-alphaOvarian NeoplasmsRecombinant ProteinsJournal ArticleResearch Support, Non-U.S. Gov't

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M O Nicoletto, M V Fiorentino, O Vinante, A Prosperi, F Tredese, S Tumolo, G P Cima, S Monfardini. 1992. Experience with intraperitoneal alpha-2a interferon.. https://doi.org/10.1159/000227094

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