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PubMed · 14653709

Frozen-solution conformational analysis by REDOR spectroscopy.

Luis J Smith·Fabien P Boulineau·Daniel Raftery·Alexander Wei
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Abstract

Frozen-solution conformational analysis (FrSCA) can be performed on organic compounds using REDOR spectroscopy. REDOR measurements on frozen aqueous solutions of 13C-methyl beta-15N-aminoglucoside indicate a bimodal distribution of conformations in a 68:32 ratio, with 13C-15N distances of 4.31 and 3.55 A, respectively. The high resolution and straightforward sample preparation make FrSCA an attractive alternative to solution-based NMR methods of conformational analysis.

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AcetylglucosamineCarbon IsotopesFreezingGlycineMagnetic Resonance SpectroscopyModels, MolecularMolecular ConformationNitrogen IsotopesNuclear Magnetic Resonance, BiomolecularThermodynamicsJournal ArticleResearch Support, Non-U.S. Gov't

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Luis J Smith, Fabien P Boulineau, Daniel Raftery, Alexander Wei. 2003-12-10. Frozen-solution conformational analysis by REDOR spectroscopy.. https://doi.org/10.1021/ja036526b

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