Cell migration: integrating signals from front to back.

Anne J Ridley; Martin A Schwartz; Keith Burridge; Richard A Firtel; Mark H Ginsberg; Gary Borisy; J Thomas Parsons; Alan Rick Horwitz

doi:10.1126/science.1092053

PubMed · 14657486

Cell migration: integrating signals from front to back.

Anne J Ridley·Martin A Schwartz·Keith Burridge·Richard A Firtel·Mark H Ginsberg·Gary Borisy·J Thomas Parsons·Alan Rick Horwitz

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Abstract

Cell migration is a highly integrated multistep process that orchestrates embryonic morphogenesis; contributes to tissue repair and regeneration; and drives disease progression in cancer, mental retardation, atherosclerosis, and arthritis. The migrating cell is highly polarized with complex regulatory pathways that spatially and temporally integrate its component processes. This review describes the mechanisms underlying the major steps of migration and the signaling pathways that regulate them, and outlines recent advances investigating the nature of polarity in migrating cells and the pathways that establish it.

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Actin Cytoskeleton Animals Cell Adhesion Cell Movement Cell Polarity Humans Integrins Models, Biological Proteins Pseudopodia Signal Transduction Journal Article Review

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Anne J Ridley, Martin A Schwartz, Keith Burridge, Richard A Firtel, Mark H Ginsberg, Gary Borisy, J Thomas Parsons, Alan Rick Horwitz. 2003-12-05. Cell migration: integrating signals from front to back.. https://doi.org/10.1126/science.1092053

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