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PubMed · 14659692

SAM domains: uniform structure, diversity of function.

Chongwoo A Kim·James U Bowie
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Abstract

Sterile alpha motif (SAM) domains are known to exhibit diverse protein-protein interaction modes. They can form multiple self-association architectures and also bind to various non-SAM domain-containing proteins. Surprising new work adds a completely unanticipated function for some SAM domains - the ability to bind RNA. Such functional diversity within a homologous protein family presents a significant challenge for bioinformatic function assignment.

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Binding SitesModels, MolecularProtein BindingProtein ConformationProtein Structure, SecondaryProtein Structure, TertiaryProteinsReceptor Protein-Tyrosine KinasesSchizosaccharomyces pombe ProteinsJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.

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Chongwoo A Kim, James U Bowie. 2003. SAM domains: uniform structure, diversity of function.. https://doi.org/10.1016/j.tibs.2003.11.001

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