A paramagnetic CEST agent for imaging glucose by MRI.

Shanrong Zhang; Robert Trokowski; A Dean Sherry

doi:10.1021/ja038345f

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A paramagnetic CEST agent for imaging glucose by MRI.

Shanrong Zhang·Robert Trokowski·A Dean Sherry

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Abstract

The europium(III) complex of a DOTA-tetraamide ligand (DOTA = 1,4,7,10-tetraazacyclododecane-N,N',N' ',N' ''-tetraacetic acids) containing two phenyl boronate pendent arms binds glucose reversibly with an association constant of 383 M-1 at pH 7. Glucose binding results in slowing of water exchange between a single Eu(III)-bound water molecule and bulk water, and this can be imaged by MRI using chemical exchange saturation transfer (CEST) imaging sequence. This metabolite-responsive paramagnetic CEST agent responds to changes in glucose over the physiologically important range (0-20 mM), and thus it offers the possibility of high-sensitivity MR imaging glucose in tissues using bulk water protons as antenna.

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Boronic Acids Contrast Media Europium Glucose Magnetic Resonance Imaging Organometallic Compounds Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

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Shanrong Zhang, Robert Trokowski, A Dean Sherry. 2003-12-17. A paramagnetic CEST agent for imaging glucose by MRI.. https://doi.org/10.1021/ja038345f

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