Mycobacterium tuberculosis: a model system for structural genomics.

Clare V Smith; James C Sacchettini

doi:10.1016/j.sbi.2003.10.004

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Mycobacterium tuberculosis: a model system for structural genomics.

Clare V Smith·James C Sacchettini

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Abstract

Over the past five years, genomics has had a major impact on Mycobacterium tuberculosis research. With the publication of the sequences of two virulent strains (H37Rv and CDC1551) and three closely related sequences, M. tuberculosis is becoming a model system for proteomics and structural genomics initiatives. Together with the promise of structures of proteins with novel folds, high-resolution structures of drug targets are providing the basis for rational inhibitor design, with the goal of the development of novel anti-tuberculars. In addition, this work is aiding scientists in the quest for an effective vaccine against this persistent pathogen.

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Animals Antitubercular Agents Bacterial Proteins Drug Delivery Systems Drug Design Gene Expression Regulation, Bacterial Genomics Humans Mycobacterium tuberculosis Protein Conformation Protein Folding Protein Structure, Secondary Protein Structure, Tertiary Structure-Activity Relationship Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.Review

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Clare V Smith, James C Sacchettini. 2003. Mycobacterium tuberculosis: a model system for structural genomics.. https://doi.org/10.1016/j.sbi.2003.10.004

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