PubMed Health⌕ Search
Home/Archive/PubMed

PubMed · 1467657

[Thyroid regulation pathways and its effect on human luteal function].

W Würfel
View original source ↗Export metadata ↓

Abstract

There are interferences between function of the thyroid gland and the ovary. Thus, thyroid disorders may influence the ovarian cycle. Up to now interferences in three main areas are described: the secretion of GnRH, i.e. FSH and, above all, LH, the peripheral metabolism of steroids (androgens, estrogens, and SHBG), and metabolism of prolactin. By employing human luteal cells, we were able to demonstrate that there is also a direct impact of thyroid regulation on luteal function: TSH, but not TRH or T3 or T4, possesses a luteotropic activity and reaches one fifth of the biological activity of hCG. This kind or direct influence may play an important role in the pathophysiology in patients with hypothyroidism.

Explore related subjects

FeedbackFemaleGonadal Steroid HormonesHumansHypothalamo-Hypophyseal SystemInfertility, FemaleLuteal PhaseOvulationThyroid Function TestsThyroid GlandThyroid HormonesEnglish AbstractJournal ArticleReview

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

W Würfel. 1992. [Thyroid regulation pathways and its effect on human luteal function].. https://doi.org/10.1159/000271870

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed1992

Three-dimensional drawings in isometric conditions: planar segmentation of force trajectory.

Normal human subjects grasped an isometric handle with an unrestrained, pronated hand. They were asked to exert forces continuously to draw lemniscates (figure eights) in specified or self-chosen planes and in the presence or absence of a three-dimensional visual feedback cursor and a visual template. In every condition, the mean plane orientation in the force space differed appreciably between the two loops of the figure, as described previously by Soechting and Terzuolo (1987a) for free drawing arm movements. These findings suggest that the planar segmentation of the motor trajectory is not a consequence of joint motion but arises from central constraints related to the production of motor trajectory in space.

Feedback↗
PubMed1992

Influences of hand movements on eye movements in tracking tasks in man.

We investigated horizontal smooth pursuit eye movements and hand movements in tracking tasks in order to find out whether hand movements influence eye movements and if so, in what ways. Externally controlled target movements were tracked either by the eyes alone or by the eyes and right hand together. Because a possible influence might depend on the stimulus, we used two classes of target movements: sinusoidal target movements (predictable target movements) and pseudo-random target movements (unpredictable target movements). Our data show that the eye movements contained only a few small saccades when sinusoidal target movements with frequencies higher than about 1 Hz were tracked by eyes and hand together. More and larger saccades were made when the same target movements were tracked by the eyes alone. The difference in smoothness of eye movements was highly significant between the two tracking conditions. Such a difference was not found during the tracking of a pseudo-random target motion. This suggests that the influence of hand movements is related to the predictability of the stimulus. In contrast to the gain of the smooth pursuit eye movements and the maximum of the cross-correlation function, the gain of the composite eye movements did not depend on the tracking condition. The delay of the eye movements with respect to the (sinusoidal) target movements also showed no dependence on the tracking condition. Visual feedback from the tracking hand was found not to play a role in the difference in eye movements for the two tracking conditions.

Feedback↗