PubMed · 14686408
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David Concar. 2003-05-03. Test blunders risk needless abortions.. https://pubmed.ncbi.nlm.nih.gov/14686408/
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The present study was performed between 1992 and 1998 and had the aim of examining the activity and side-effects of intravenously administered sulprostone for the induction of abortion in the second trimester. 160 patients were admitted to hospital. 3 were submitted to a hysterectomy; 3 underwent an abortion after cervical priming with Prostin E2 Gel (0.25 mg/ml), 154 were repeatedly treated with an infusion of sulprostone for 6 hours (500 microg Nalodor, 3 A/1000 ml 0.9% NaCl, 250 microg/h (equivalent to 4.17 microg or ca. 55 drops per min.). The mean interval for induction of abortion was 16 h 56 min; 53% of the abortions occurred within 12h; 95% of the abortions occurred within 48 h. Two inductions were unsuccessful. 12 women suffered from atonic bleeding. This study demonstrated that sulprostone infusions are suitable for the induction of abortions in the second trimester and that side-effects are rare. Particular attention must be paid to the complication of bleeding.
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OBJECTIVES: To analyse the management of pregnancy after prenatal diagnosis of sex chromosome aneuploidy (SCA) and the factors influencing genetic counselling and parental decision. METHODS: Between 1991 and 2001, 73 non-mosaic fetal SCA were diagnosed in our centre and 25 were referred to us from outside institutions. The same geneticist carried out genetic counselling. The outcome of pregnancies and the termination trend over time were determined according to the type of SCA. Clinical parental data were analysed in order to assess whether they influenced genetic counselling. RESULTS: 45,X was diagnosed in 41 fetuses. The main indication for karyotyping was abnormal ultrasound (83%). The termination rate was 93%. Sex chromosome polysomies (SCP) including 47,XXY, 47,XXX, and 47,XYY were diagnosed in 31, 16, and 10 fetuses respectively. The main indication for karyotyping was advanced maternal age (60%). The termination rate was 32, 25, and 20% respectively. The difference between the termination rate for local cases (25%) and referred cases (33%) was not significant. The termination rate for pregnancies with SCP was 38% in 1991 to 1994, 34% in 1995 to 1998, and 12% in 1999 to 2001. The parents' characteristics did not influence the outcome of pregnancy. CONCLUSIONS: The relatively low termination rate (28%) in pregnancies where the fetus was affected by SCP and the decreasing termination trend over time in our centre suggest an improved knowledge of the pathological conditions associated with SCP, influencing genetic counselling.