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PubMed · 14701994

Estimation of active cortical current source regions using a vector representation scanning approach.

Anthony L Ricamato·Yasin Y Dhaher·Julius P A Dewald
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Abstract

The objective of this article is to present a framework for cortical current source reconstruction that extracts a center and magnitude of electrical brain activity from EEG signals. High-resolution EEG recordings, a subject-specific MRI-based electromagnetic boundary element method (BEM) model, and a channel reduction technique are used. This new geometric measure combines the magnitude and spatial location of electrical brain activity of each of the identified subsets of channels into a three-dimensional resultant vector. The combination of the two approaches constitutes a source reconstruction scanning technique that provides a real-time estimation of cortical centers that can be tracked over time. Simulations demonstrate that the ability of this method to find the best-fit cortical location is more robust both in terms of accuracy and precision than traditional approaches for single-source conditions. Experimental validation demonstrates its ability to localize and separate cortical activity in plausible sites for two different motor tasks. Finally, this method provides a statistical measure to compare electrical brain activity associated with different motor tasks.

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AdultAlgorithmsAnalysis of VarianceBrain MappingCerebral CortexChi-Square DistributionComputer SimulationElectroencephalographyFemaleHumansMagnetic Resonance ImagingMagnetoencephalographyMaleModels, NeurologicalReproducibility of ResultsSensitivity and SpecificitySpace PerceptionTime FactorsComparative StudyJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.

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Anthony L Ricamato, Yasin Y Dhaher, Julius P A Dewald. Estimation of active cortical current source regions using a vector representation scanning approach.. https://doi.org/10.1097/00004691-200309000-00005

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