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Thyroliberin (TRH) increases thymus cell proliferation in rats.

M Pawlikowski·G Zerek-Mełeń·K Winczyk
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Abstract

The effects of thyroliberin (TRH), a TRH-like tripeptide colon mitosis inhibitor (CMI), a somatostatin analog SMS 201-995 and metoclopramide (dopamine receptor antagonist enhancing prolactin secretion) on rat thymus cell proliferation were investigated. The incorporation of bromodeoxyuridine (BrDU) into thymic cell nuclei was used as an index of the proliferation. It was found that TRH, but not other compounds investigated herein, increased the thymus cell proliferation 12 hours after the injection.

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Amino Acid SequenceAnimalsBromodeoxyuridineCell DivisionMaleMetoclopramideMolecular Sequence DataOctreotideOligopeptidesPyrrolidonecarboxylic AcidRatsRats, WistarThymus GlandThyrotropin-Releasing HormoneJournal Article

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M Pawlikowski, G Zerek-Mełeń, K Winczyk. 1992. Thyroliberin (TRH) increases thymus cell proliferation in rats.. https://doi.org/10.1016/0143-4179(92)90123-e

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