Tumefactive myelinoclastic diffuse sclerosis--case report.

Soichi Obara; Hideo Takeshima; Ryuji Awa; Hajime Yonezawa; Tatsuki Oyoshi; Tetsuya Nagayama; Hirofumi Hirano; Masaki Niiro; Jun-ichi Kuratsu

doi:10.2176/nmc.43.563

PubMed · 14705325

Tumefactive myelinoclastic diffuse sclerosis--case report.

Soichi Obara·Hideo Takeshima·Ryuji Awa·Hajime Yonezawa·Tatsuki Oyoshi·Tetsuya Nagayama·Hirofumi Hirano·Masaki Niiro·Jun-ichi Kuratsu

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Abstract

A 6-year-old boy presented with mental disturbance and progressive left hemiparesis. Magnetic resonance imaging demonstrated large intracranial mass lesions with ring-like enhancement. His neurological condition deteriorated rapidly. Open biopsy via craniotomy was performed under the suspicion of tumor. Histological examination showed massive demyelination and axon preservation, but no tumor cells. The diagnosis was myelinoclastic diffuse sclerosis (MDS). He was treated with high-dose methylprednisolone and improved dramatically. MDS is a rare demyelinating disorder of the central nervous system that affects mainly children and may mimic a brain tumor. MDS must be included in the differential diagnosis in young patients with a brain tumor with atypical radiological appearance.

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Brain Neoplasms Child Diagnosis, Differential Diffuse Cerebral Sclerosis of Schilder Gait Hemiplegia Humans Male Mental Disorders Case Reports Journal Article

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Soichi Obara, Hideo Takeshima, Ryuji Awa, Hajime Yonezawa, Tatsuki Oyoshi, Tetsuya Nagayama, Hirofumi Hirano, Masaki Niiro, Jun-ichi Kuratsu. 2003. Tumefactive myelinoclastic diffuse sclerosis--case report.. https://doi.org/10.2176/nmc.43.563

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