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PubMed · 14708010

Tubby proteins: the plot thickens.

Kilpatrick Carroll·Carlos Gomez·Lawrence Shapiro
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Abstract

The tubby mouse, which shows late-onset obesity and neurosensory deficits, arises from a mutation in the Tub gene. Tub shares homology with the genes for tubby-like proteins Tulp1, Tulp2 and Tulp3. Ablation of Tub, Tulp1 or Tulp3 causes disease phenotypes that are indicative of their importance in nervous-system function and development. Despite this importance, the biochemical functions of tubby-like proteins are only now beginning to be understood. At present, data indicate that tubby-like proteins might function as heterotrimeric-G-protein-responsive intracellular signalling factors, although an array of data also implicates them in other processes.

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Adaptor Proteins, Signal TransducingAnimalsEmbryonic and Fetal DevelopmentEye ProteinsGene Expression Regulation, DevelopmentalMiceMice, KnockoutMutationNervous System DiseasesObesityPoint MutationProteinsJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.Review

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Kilpatrick Carroll, Carlos Gomez, Lawrence Shapiro. 2004. Tubby proteins: the plot thickens.. https://doi.org/10.1038/nrm1278

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