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High-throughput nuclear magnetic resonance analysis using a multiple coil flow probe.

Megan A Macnaughtan·Ting Hou·Jun Xu·Daniel Raftery
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Abstract

An automated method for high-throughput nuclear magnetic resonance (NMR) spectroscopy has been developed using a four-coil Multiplex NMR probe. The probe is constructed with solenoidal microcoils optimized for detection of small volume, mass-limited samples and a flow-through design. Four samples can be simultaneously injected into the Multiplex probe with a robotics liquid handler and then analyzed in rapid succession using a selective excitation experiment. Due to the simultaneous injection of four samples and the reduced analysis time with rapid selective excitation, the analysis rate achieved thus far is as low as 1 sample/34 s for 1D 1H NMR.

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Magnetic Resonance SpectroscopyJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, Non-P.H.S.

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Megan A Macnaughtan, Ting Hou, Jun Xu, Daniel Raftery. 2003-10-01. High-throughput nuclear magnetic resonance analysis using a multiple coil flow probe.. https://doi.org/10.1021/ac034400r

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