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TGF-beta: how tolerant can it be?

Sharon M Wahl·Wanjun Chen
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Abstract

A balance between an adequate immune response to an antigen or pathogen and tolerance is a prerequisite for normal immune homeostasis and the well-being of the host. In this complex self-regulation, multiple mechanisms have been implicated as contributing to the immune tolerance network, including apoptosis, anergy, and active suppression. Current excitement focuses on active suppression and new regulatory T cell-mediated pathways of immunosuppression that are being unraveled. Central to several of these pathways is transforming growth factor-beta (TGF-beta), a potent immunoregulatory cytokine that contributes to the function and generation of regulatory T cells.

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AnimalsAntigens, CDAntigens, DifferentiationAutoimmune DiseasesCD4-Positive T-LymphocytesCTLA-4 AntigenGlucocorticoid-Induced TNFR-Related ProteinHumansImmune ToleranceInterleukin-2Membrane GlycoproteinsMiceModels, ImmunologicalReceptors, Cell SurfaceReceptors, Interleukin-2Receptors, Nerve Growth FactorReceptors, Tumor Necrosis FactorT-Lymphocyte SubsetsToll-Like ReceptorsTransforming Growth Factor betaJournal ArticleReview

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Sharon M Wahl, Wanjun Chen. 2003. TGF-beta: how tolerant can it be?. https://doi.org/10.1385/ir%3A28%3A3%3A167

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